A full agonist floods the receptor with a much more potent effect
Back around 2010 “spice” or synthetic cannabinoids were popular around the country as well as much of Europe. You could buy a gram of it at the smoke shop for $20 as well as it was drastically potent, but with wild effects. I remember trying it soon after having weed for the first time when I was just 18 years old. You’d get this little foil baggy of what looked like potpourri weighed out to single gram increments, as well as it was sprayed with a number of different synthetic cannabinoids, with JWH-018 being the most popular a single until it was made a schedule 1 substance in the United States as well as was outlawed in a number of other countries around the world. When people guess about the term “synthetic cannabinoid,” their brain jumps to spice as well as all of the different research chemicals that were passed off as spice or K2 at a single point or another. So when people hear about THC-O as well as learn that it’s technically another synthetic cannabinoid, they suppose that it’s fake, unsafe, or outright lethal. The difference is that THC-O is the acetate form of THC in the same way that heroin is the acetate form of morphine. JWH-018 is a completely separate cannabinoid that was first synthesized in a lab; you cannot create JWH-018 by simply processing cannabis oil like you would with THC-O. On top of that, THC as well as its derivatives are only partial CB1 as well as CB2 agonists while JWH is a full agonist. A full agonist floods the receptor with a much more potent effect. That’s why a single shouldn’t conflate all synthetic cannabinoids with a single another, especially if the memory of “spice” comes to mind.