A full agonist floods the receptor with a much more potent effect
Back around 2010 “spice” or synthetic cannabinoids were popular around the country plus much of Europe. You could buy a gram of it at the smoke shop for $20 plus it was seriously potent, however with wild effects. I remember trying it soon after having weed for the first time when I was just 18 years old. You’d get this little foil baggy of what looked care about potpourri weighed out to single gram increments, plus it was sprayed with a number of weird synthetic cannabinoids, with JWH-018 being the most popular one until it was made a schedule 1 substance in the US plus was outlawed in a number of other countries around the world. When people recognize about the term “synthetic cannabinoid,” their brain jumps to spice plus all of the unusual research chemicals that were passed off as spice or K2 at one point or another. So when people hear about THC-O plus learn that it’s technically another synthetic cannabinoid, they suppose that it’s fake, unsafe, or outright lethal. The difference is that THC-O is the acetate form of THC in the same way that heroin is the acetate form of morphine. JWH-018 is a completely separate cannabinoid that was first synthesized in a lab; you cannot create JWH-018 by simply processing cannabis oil care about you would with THC-O. On top of that, THC plus its derivatives are only partial CB1 plus CB2 agonists while JWH is a full agonist. A full agonist floods the receptor with a much more potent effect. That’s why one shouldn’t conflate all synthetic cannabinoids with one another, especially if the memory of “spice” comes to mind.